The B-32 was initially intended as insurance against failure of the B-29 program. However, the success of B-29 development and operational deployment made cancellation of the Dominator a very real possibility at several points in its development. The Army Air Forces wanted to begin replacing B-17s and B-24s with B-32s in the summer of 1944. The plan called for Mediterranean based B-24 bomb groups to transition first, followed by other groups in the 15th Air Force and finally 8th Air Force groups. However, because the B-32 test program was so far behind schedule, not a single B-32 was ever sent to the Mediterranean or European Theaters of Operation.

In December 1944, the B-32 program was almost canceled again. This time it was saved pending completion of a service test program. While the service test proceeded, combat crew training was started in preparation for deployment to the Pacific (pending a successful service test.) The service test revealed several minor and a few major problems and the program was near cancellation once again in the spring of 1945.

In March 1945, General George Kenney, Commander of the Far Eastern Air Forces (5th AF), traveled to Washington D.C. to ask for B-32s. He wanted B-29s but was turned down because of higher priority needs elsewhere in the PTO. After demonstrations in Washington, General Kenney convinced the Army General Staff to allow him to conduct a combat evaluation of the Dominator. A combat test plan of eleven missions was planned and if successful, the B-32 was scheduled to replace all the B-24 groups in the Pacific Theater. Three B-32s were assigned to the 386th Bomb Squadron, 312th Bomb Group, 5th Air Force. The first combat test mission was flown against a supply depot at Antatet, Luzon, Philippines on 29 May 1945. The last mission of the generally successful combat test was flown on 25 June 1945 against bridges near Kiirun on the island of Formosa (Taiwan).

The 386th Bomb Squadron completed B-32 transition in July 1945 and flew six operational combat missions before the end of the war. Following the 9 August 1945 bombing of Nagasaki, the 386th conducted photo reconnaissance missions and were attacked by flak and fighters on 17 August and again by Japanese fighters on the 18th. Although no Dominator was lost in combat, at least two were damaged. Sergeant Marchione, a photographer aboard one of the B-32s on the photo reconnaissance mission of 18 August 1945, was killed when his bomber was attacked by fighters.

The last B-32 combat mission (also photo recon) was completed on 28 August 1945. The 386th BS was ordered to cease combat operations two days later. Cancellation of the B-32 program came on 8 September 1945 and production of Dominators was halted on 12 October. Flyable aircraft at Consolidated factories were flown directly to the scrap yard and all partially built B-32s were scrapped at the factory. The last remaining B-32 was scrapped in the summer of 1949.